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http://cicy.repositorioinstitucional.mx/jspui/handle/1003/506| Antigiardial activity of flavonoids from leaves of Aphelandra scabra | |
| SERGIO RUBEN PERAZA SANCHEZ | |
| GLORIA IVONNE HERNANDEZ BOLIO LUIS WILIUNFO TORRES TAPIA ROSA ESTHER MOO PUC | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| DOI: 10.1016/j.bjp.2015.04.004 | |
| ACANTHACEAE ANTI-GIARDIAL ACTIVITY APHELANDRA SCABRA CIRSIMARITIN FLAVONOIDS | |
| Aphelandra scabra (Vahl) Sm., Acanthaceae, is a shrub widely used by some Mayan communities as carminative, antidote, and remedy for some infections. Bio-guided isolation of the methanol extract of leaves led us to the purification of the anti-giardial metabolites cirsimaritin and sorbifolin, along with the inactive metabolites cirsimarin, sorbifolin-6-O-β-glucopyranoside, and squalene. Cirsimaritin displayed high activity in the anti-giardial bioassay with an IC50 = 3.8 µM, being considered as outstanding when compared to previous reported metabolites, while sorbifolin showed a low activity with an IC50 = 75.6 µM. Additionally, both compounds proved not to be cytotoxic in an in vitro bioassay against HEK-293, a normal cell line. This is the first investigation on anti-giardial properties of A. scabra and its phytochemistry as well, thus the isolated compounds are considered as new for the plant genus and for the species. | |
| 01-05-2015 | |
| Artículo | |
| Brazilian Journal of Pharmacognosy. 25(3), 233-237, 2015 | |
| Inglés | |
| Hernández-Bolio, G. I., Torres-Tapia, L. W., Moo-Puc, R., & Peraza-Sánchez, S. R. (2015). Antigiardial activity of flavonoids from leaves of aphelandra scabra. Brazilian Journal of Pharmacognosy, 25(3), 233-237. doi:10.1016/j.bjp.2015.04.004 | |
| BIOLOGÍA Y QUÍMICA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
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