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http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1075| Fibrillarin from Archaea to human | |
| ULISES RODRIGUEZ CORONA MARGARITA SOBOL LUIS CARLOS RODRIGUEZ ZAPATA PAVEL HOZAK ENRIQUE CASTAÑO DE LA SERNA | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| DOI: 10.1111/boc.201400077 | |
| CANCER METHYLATION P53 RIBOSOMAL BIOGÉNESIS RNA PROCESSING | |
| Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negative regulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection. | |
| 2015 | |
| Artículo | |
| Biology of the Cell, 107(6), 159-174, 2015 | |
| Inglés | |
| Rodriguez‐Corona, U., Sobol, M., Rodriguez‐Zapata, L. C., Hozak, P., & Castano, E. (2015). Fibrillarin from Archaea to human. Biology of the Cell, 107(6), 159-174. | |
| BIOLOGÍA Y QUÍMICA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
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| 2015_id35312_Rodriguez_Corona.pdf | 845.2 kB | Adobe PDF | Visualizar/Abrir |