Please use this identifier to cite or link to this item: http://cicy.repositorioinstitucional.mx/jspui/handle/1003/115
Antituberculosis activity of alkylated mulinane diterpenoids
LUIS MANUEL PEÑA RODRIGUEZ
Acceso Abierto
Atribución-NoComercial-SinDerivadas
Natural azorellane and mulinane diterpenoids show antituberculosis activity, which is increased by methylation of their free carboxyl group. We have systematically investigated the effect of alkylation in this class of diterpenoids and found that the profile of bioactivity is relatively unaffected by the introduction of short alkyl groups, both linear and branched. In this investigation, three semisynthetic diterpenoids, 13 hydroxy-mulin-11-en-20-oic acid n-propyl ester (3) and the n-propyl (19) and n-butyl (20) esters of isomulinic acid, showed the strongest antituberculosis activity (MIC =6.25 μg/mL) against a drug-resistant strain of Mycobacterium tuberculosis.
04-04-2010
Artículo
Inglés
CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA
Appears in Collections:Artículos de Investigación Arbitrados

Upload archives


File Description SizeFormat 
13512.pdf266.5 kBAdobe PDFView/Open