Por favor, use este identificador para citar o enlazar este ítem:
http://cicy.repositorioinstitucional.mx/jspui/handle/1003/115| Antituberculosis activity of alkylated mulinane diterpenoids | |
| LUIS MANUEL PEÑA RODRIGUEZ | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| Natural azorellane and mulinane diterpenoids show antituberculosis activity, which is increased by methylation of their free carboxyl group. We have systematically investigated the effect of alkylation in this class of diterpenoids and found that the profile of bioactivity is relatively unaffected by the introduction of short alkyl groups, both linear and branched. In this investigation, three semisynthetic diterpenoids, 13 hydroxy-mulin-11-en-20-oic acid n-propyl ester (3) and the n-propyl (19) and n-butyl (20) esters of isomulinic acid, showed the strongest antituberculosis activity (MIC =6.25 μg/mL) against a drug-resistant strain of Mycobacterium tuberculosis. | |
| 04-04-2010 | |
| Artículo | |
| Inglés | |
| CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
Cargar archivos:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| 13512.pdf | 266.5 kB | Adobe PDF | Visualizar/Abrir |