Por favor, use este identificador para citar o enlazar este ítem:
http://cicy.repositorioinstitucional.mx/jspui/handle/1003/122| In vitro and in vivo trypanocidal activity of native plants from the Yucatan Peninsula | |
| LUIS MANUEL PEÑA RODRIGUEZ | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| Ethanol extracts of Senna villosa, Serjania yucatanensis, Byrsonima bucidaefolia, and Bourreria pulchra were evaluated for their in vitro activity against epimastigotes and trypomastigotes ofTrypanosoma cruzi. Results showed that the leaf extracts ofS. yucatanensisand B. pulchra were the most active against epimastigotes (IC100=100μg/mL) and trypomastigotes ofT. cruzi(95% or more reduction in the number of parasites at 100 and 50μg/mL). However, only the leaf extract ofS. yucatanensisshowed significant trypanocidal activity when tested in vivo, reducing 75% of the parasitemia in infected mice at 100 mg/kg. This same extract inhibited the egress of trypomastigotes from infected cells and proved not to be cytotoxic (IC50=318.8±2.3μg/mL). | |
| 02-01-2012 | |
| Artículo | |
| CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
Cargar archivos:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| 18369.pdf | 280.73 kB | Adobe PDF | Visualizar/Abrir |