Please use this identifier to cite or link to this item: http://cicy.repositorioinstitucional.mx/jspui/handle/1003/122
In vitro and in vivo trypanocidal activity of native plants from the Yucatan Peninsula
LUIS MANUEL PEÑA RODRIGUEZ
Acceso Abierto
Atribución-NoComercial-SinDerivadas
Ethanol extracts of Senna villosa, Serjania yucatanensis, Byrsonima bucidaefolia, and Bourreria pulchra were evaluated for their in vitro activity against epimastigotes and trypomastigotes ofTrypanosoma cruzi. Results showed that the leaf extracts ofS. yucatanensisand B. pulchra were the most active against epimastigotes (IC100=100μg/mL) and trypomastigotes ofT. cruzi(95% or more reduction in the number of parasites at 100 and 50μg/mL). However, only the leaf extract ofS. yucatanensisshowed significant trypanocidal activity when tested in vivo, reducing 75% of the parasitemia in infected mice at 100 mg/kg. This same extract inhibited the egress of trypomastigotes from infected cells and proved not to be cytotoxic (IC50=318.8±2.3μg/mL).
02-01-2012
Artículo
CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA
Appears in Collections:Artículos de Investigación Arbitrados

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