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Metabolites from the leaf extract ofSerjania yucatanensis with trypanocidal activity againstTrypanosoma cruzi
Acceso Abierto
he bioassay-guided phytochemical investigation of the leaf extract ofSerjania yucatanensis, a woody climbing plant endemic to the Yucatan peninsula, led to the identification of a mixture of a triterpene [lup-20(29)-en-3-one] and an oxygenated sesquiterpene (β-caryophyllene oxide), as that responsible for the originally detected trypanocidal activity in the organic crude extract. Results showed that the mixture of lup-20(29)-en-3-one andβ-caryophyllene oxide is active against trypomastigotes of Trypanosoma cruzi(IC500 80.3μg/mL) and inhibits the egress of trypomastigotes from infected Vero cells (when tested at 100μg/mL) without being cytotoxic. Introduction Chagas disease, caused by the hemoflagellate protozoan Trypanosoma cruzi, affects about ten million people in Central and South America (WHO2010). Currently available chemotherapy for the treatment of Chagas disease is unsatisfactory, with the efficiency of pharmaceuticals such as benznidazole, nifurtimox, and allopurinol being low (ca. 50%) and their side effects considerable (Rodrigues and de Castro2002; Castro and Montalvo 2006). Because of this, the WHO has emphasized the need to develop new and better trypanocidal drugs with none or limited side effects (WHO2000). Presently, and although the import role played by natural products in drug discovery is well recognized (Newman and Cragg2007), it is estimated that only a small fraction of plants have been studied for their production of bioactive metabolites (Harvey2000). In Mexico, the Yucatan peninsula has a characteristic native flora that includes 2,300 species of flowering plants, 168 of which are considered to be native or endemic (Pulido
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