Por favor, use este identificador para citar o enlazar este ítem:
http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1528| CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the ring domain that is present across eukaryotes | |
| DOMINGO JIMENEZ LOPEZ LAURA AGUILAR HENONIN JUAN MANUEL GONZALEZ PRIETO Víctor Hugo Aguilar Hernández PLINIO ANTONIO GUZMAN VILLATE | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1371/journal.pone.0190969 | |
| CTL PROTEIN PROTEIN UBIQUITIN PROTEIN LIGASE E3 UNCLASSIFIED DRUG ZINC FINGER PROTEIN UBIQUITIN PROTEIN LIGASE | |
| RING ubiquitin E3 ligases enclose a RING domain for ubiquitin ligase activity and associated domains and/or conserved motifs outside the RING domain that collectively facilitate their classification and usually reveal some of key information related to mechanism of action. Here we describe a new family of E3 ligases that encodes a RING-H2 domain related in sequence to the ATL and BTL RING-H2 domains. This family, named CTL, encodes a motif designed as YEELL that expands 21 amino acids next to the RING-H2 domain that is present across most eukaryotic lineages. E3 ubiquitin ligase BIG BROTHER is a plant CTL that regulates organ size, and SUMO-targeted ubiquitin E3 ligase RNF111/ARKADIA is a vertebrate CTL. Basal animal and vertebrate, as well as fungi species, encode a single CTL gene that constraints the number of paralogs observed in vertebrates. Conversely, as previously described in ATL and BTL families in plants, CTL genes range from a single copy in green algae and 3 to 5 copies in basal species to 9 to 35 copies in angiosperms. Our analysis describes key structural features of a novel family of E3 ubiquitin ligases as an integral component of the set of core eukaryotic genes. | |
| 2018 | |
| Artículo | |
| PloS one, 13(1), e0190969, 2018 | |
| Inglés | |
| Jiménez-López, D., Aguilar-Henonin, L., González-Prieto, J. M., Aguilar-Hernández, V., & Guzmán, P. (2018). CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the RING domain that is present across eukaryotes. PloS one, 13(1), e0190969. | |
| BIOLOGÍA Y QUÍMICA | |
| Versión revisada | |
| submittedVersion - Versión revisada | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| 2018_Domingo_Jimenez.pdf | 8.02 MB | Adobe PDF | Visualizar/Abrir |