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http://cicy.repositorioinstitucional.mx/jspui/handle/1003/157| Cytotoxic constituents from the stem bark ofDiospyros cuneataStandl. | |
| ROCIO DE LOURDES BORGES ARGAEZ | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| A phytochemical investigation of the stem bark ofDiospyros cuneata(Ebenaceae) together within vitro cytotoxic evaluation of the pure compounds in four human cancer cell lines KB, Hep-2, HeLa and SiHa led to the isolation of plumbagin, elliptinone, lupeol, atraric acid methyl ester, maritinone, betulin and betulinaldehyde. The structural determination of the compounds was established by nuclear magnetic resonance, electron ionisation mass spectrometric analysis as well as comparison with data from the literature. Plumbagin exhibited a potent cytotoxic activity (CC50¼3.56mgmL 1 ) against KB cell lines whereas maritinone displayed cytotoxic activity against Hep-2 (CC50¼17.30mgmL 1 ), cervical cancer (CC50¼21.10mgmL 1 ) and the KB cell lines (CC50¼20.30mgmL 1 ). This is the first report on a phytochemical and biological evaluation of D. cuneata. | |
| 26-10-2012 | |
| Artículo | |
| CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
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