Please use this identifier to cite or link to this item: http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1605
Flourensia cernua: Hexane extracts a very active mycobactericidal fraction from an inactive leaf decoction against pansensitive and panresistant Mycobacterium tuberculosis
GLORIA MARIA MOLINA SALINAS
Luis Manuel Peña Rodríguez
BENITO DAVID MATA CARDENAS
Fabiola Escalante Erosa
DIMNA SILVIA GONZALEZ HERNANDEZ
VICTOR MANUEL TORRES DE LA CRUZ
HERMINIA GUADALUPE MARTINEZ RODRIGUEZ
Salvador Said_Fernández
Acceso Abierto
Atribución-NoComercial-SinDerivadas
ACETIC ACID ETHYL ESTER
ALCOHOL
BUTANOL
FLOURENSIA CERNUA DECOCTION
HEXANE
SOLVENT
UNCLASSIFIED DRUG
The efficacy of decoction in extracting mycobactericidal compounds from Flourensia cernua (Hojasé) leaves and fractionation with solvents having ascending polarity was compared with that of (i) ethanol extraction by still maceration, extraction with a Soxhlet device, shake-assisted maceration, or ultrasound-assisted maceration, followed by fractionation with n-hexane, ethyl acetate, and n-butanol; (ii) sequential extraction with n-hexane, ethyl acetate, and n-butanol, by still maceration, using a Soxhlet device, shake-assisted maceration, or ultrasound-assisted maceration. The in vitro mycobactericidal activity of each preparation was measured against drug-sensitive (SMtb) and drug-resistant (RMtb) Mycobacterium tuberculosis strains. The results of which were expressed as absolute mycobactericidal activity (AMA). These data were normalized to the ΣAMA of the decoction fraction set. Although decoction was inactive, the anti-RMtb normalized ΣAMA (NAMA) of its fractions was comparable with the anti-RMtb NAMA of the still maceration extracts and significantly higher than the anti-SMtb and anti-RMtb NAMAs of every other ethanol extract and serial extract and fraction. Hexane extracted, from decoction, material having 55.17% and 92.62% of antituberculosis activity against SMtb and RMtb, respectively. Although the mycobactericidal activity of decoction is undetectable; its efficacy in extracting F. cernua active metabolites against M. tuberculosis is substantially greater than almost all pharmacognostic methods.
2011
Artículo
Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 782503, 9 pages, 2011.
Inglés
Molina-Salinas, G. M., Peña-Rodríguez, L. M., Mata-Cárdenas, B. D., Escalante-Erosa, F., González-Hernández, S., Torres de la Cruz, V. M., ... & Said-Fernández, S. (2011). Flourensia cernua: hexane extracts a very active mycobactericidal fraction from an inactive leaf decoction against pansensitive and panresistant Mycobacterium tuberculosis. Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 782503, 9 pages, 2011
ALCALOIDES
Versión publicada
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Appears in Collections:Artículos de Investigación Arbitrados

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