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http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1605| Flourensia cernua: Hexane extracts a very active mycobactericidal fraction from an inactive leaf decoction against pansensitive and panresistant Mycobacterium tuberculosis | |
| GLORIA MARIA MOLINA SALINAS Luis Manuel Peña Rodríguez BENITO DAVID MATA CARDENAS Fabiola Escalante Erosa DIMNA SILVIA GONZALEZ HERNANDEZ VICTOR MANUEL TORRES DE LA CRUZ HERMINIA GUADALUPE MARTINEZ RODRIGUEZ Salvador Said_Fernández | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| ACETIC ACID ETHYL ESTER ALCOHOL BUTANOL FLOURENSIA CERNUA DECOCTION HEXANE SOLVENT UNCLASSIFIED DRUG | |
| The efficacy of decoction in extracting mycobactericidal compounds from Flourensia cernua (Hojasé) leaves and fractionation with solvents having ascending polarity was compared with that of (i) ethanol extraction by still maceration, extraction with a Soxhlet device, shake-assisted maceration, or ultrasound-assisted maceration, followed by fractionation with n-hexane, ethyl acetate, and n-butanol; (ii) sequential extraction with n-hexane, ethyl acetate, and n-butanol, by still maceration, using a Soxhlet device, shake-assisted maceration, or ultrasound-assisted maceration. The in vitro mycobactericidal activity of each preparation was measured against drug-sensitive (SMtb) and drug-resistant (RMtb) Mycobacterium tuberculosis strains. The results of which were expressed as absolute mycobactericidal activity (AMA). These data were normalized to the ΣAMA of the decoction fraction set. Although decoction was inactive, the anti-RMtb normalized ΣAMA (NAMA) of its fractions was comparable with the anti-RMtb NAMA of the still maceration extracts and significantly higher than the anti-SMtb and anti-RMtb NAMAs of every other ethanol extract and serial extract and fraction. Hexane extracted, from decoction, material having 55.17% and 92.62% of antituberculosis activity against SMtb and RMtb, respectively. Although the mycobactericidal activity of decoction is undetectable; its efficacy in extracting F. cernua active metabolites against M. tuberculosis is substantially greater than almost all pharmacognostic methods. | |
| 2011 | |
| Artículo | |
| Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 782503, 9 pages, 2011. | |
| Inglés | |
| Molina-Salinas, G. M., Peña-Rodríguez, L. M., Mata-Cárdenas, B. D., Escalante-Erosa, F., González-Hernández, S., Torres de la Cruz, V. M., ... & Said-Fernández, S. (2011). Flourensia cernua: hexane extracts a very active mycobactericidal fraction from an inactive leaf decoction against pansensitive and panresistant Mycobacterium tuberculosis. Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 782503, 9 pages, 2011 | |
| ALCALOIDES | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
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