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http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1750| Nuclear phosphoinositides—Versatile regulators of genome functions | |
| Enrique Castaño de la Serna ŞÜKRİYE YILDIRIM Veronika Fáberová Alžběta Krausová Livia Ulicna Darina Paprčková Martin Sztacho Pavel Hozak | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| doi:10.3390/cells8070649 | |
| PHOSPHOINOSITIDES CELL NUCLEUS GENOME GENE EXPRESSION | |
| The many functions of phosphoinositides in cytosolic signaling were extensively studied; however, their activities in the cell nucleus are much less clear. In this review, we summarize data about their nuclear localization and metabolism, and review the available literature on their involvements in chromatin remodeling, gene transcription, and RNA processing. We discuss the molecular mechanisms via which nuclear phosphoinositides, in particular phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2), modulate nuclear processes. We focus on PI(4,5)P2’s role in the modulation of RNA polymerase I activity, and functions of the nuclear lipid islets—recently described nucleoplasmic PI(4,5)P2-rich compartment involved in RNA polymerase II transcription. In conclusion, the high impact of the phosphoinositide–protein complexes on nuclear organization and genome functions is only now emerging and deserves further thorough studies | |
| 2019 | |
| Artículo | |
| Cells, 8(7), 649, 2019. | |
| Inglés | |
| BIOLOGÍA MOLECULAR DE PLANTAS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
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| Fichero | Tamaño | Formato | |
|---|---|---|---|
| 2019_Castano.pdf | 2.61 MB | Adobe PDF | Visualizar/Abrir |