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Nanofibers of gelatin and polivinyl-alcohol-chitosan for wound dressing application: fabrication and characterization
PAOLA IVETH CAMPA SIQUEIROS
Tomás J. Madera-Santana
Jesús Fernando Ayala Zavala
JAIME LOPEZ CERVANTES
MARIA MONICA CASTILLO ORTEGA
Pedro Jesús Herrera Franco
Acceso Abierto
Atribución-NoComercial-SinDerivadas
https://doi.org/10.1590/0104-1428.07919
CHITOSAN
ELECTROSPINNING
GELATIN
PVA
WOUND DRESSING
Electrospun nanofibers from gelatin (G), chitosan (CS), and chitosan-polyvinyl alcohol (CS-PVA) were developed by electrospinning process. Mechanical properties were determined by the tensile test, the elastic modulus values of the nanofibers were G (15.418-34.34 MPa) and CS-PVA (17.44-126.427 MPa). The morphological characterization by SEM revealed that the systems with 15% G and 6% CS-PVA showed morphological homogeneity. Structural characterization by FTIR indicated an interaction among some functional groups of the component. Thermal analysis by DSC and TGA showed degradation temperatures for G (330 °C), CS (210 °C to 370 °C), and PVA (310 °C to 420 °C). The contact angles values denoted the hydrophilic nature of the material. Finally, the antimicrobial assay proved that both 15% G and 7% PVA on the CS-PVA system presented the best antimicrobial effect. The results indicate that the electrospun nanofibers fabricated with G or CS-PVA can be used as wound healing dressings.
2020
Artículo
Polímeros, 30(1), 2020
Inglés
Campa-Siqueiros, P., Madera-Santana, T. J., Ayala-Zavala, J. F., López-Cervantes, J., Castillo-Ortega, M. M., & Herrera-Franco, P. J. (2020). Nanofibers of gelatin and polivinyl-alcohol-chitosan for wound dressing application: fabrication and characterization. Polímeros, 30(1).
PROPIEDADES DE LOS MATERIALES
Versión publicada
publishedVersion - Versión publicada
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