Please use this identifier to cite or link to this item: http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1841
Preparation and characterization of electrospun fibrous scaffolds of either PVA or PVP for fast release of sildenafil citrate
ERICK JOSE TORRES MARTINEZ
Ricardo Vera Graziano
JOSE MANUEL CERVANTES UC
NINA BOGDANCHIKOVA
AMELIA OLIVAS SARABIA
RICARDO VALDEZ CASTRO
ARACELY SERRANO MEDINA
ANA LETICIA IGLESIAS
GRACIELA LIZETH PEREZ GONZALEZ
JOSE MANUEL CORNEJO BRAVO
LUIS JESUS VILLARREAL GOMEZ
Acceso Abierto
Atribución-NoComercial-SinDerivadas
10.1515/epoly-2020-0070
FIBROUS SCAFFOLDS
ELECTROSPINNING
SILDENAFIL CITRATE
POLY(VINYL ALCOHOL)
POLY(VINYL PYRROLIDONE)
Sildenafil citrate (SC) has proved to be an effective and inexpensive drug for the treatment of pulmonary arterial hypertension (PAH). This study aims to synthesize electrospun, submicron fiber scaffolds of poly(vinyl alcohol) (PVA) and poly(vinyl pyrrolidone) (PVP) loaded with SC for fast drug dissolution and its potential use in the treatment of PAH. These fiber scaffolds were prepared through the electrospinning technique. The chemical composition of the nanofibers was analyzed by Fourier transform infrared spectroscopy. Thermal stability was studied by thermogravimetric analysis and polymeric transitions by differential scattering calorimetry. Surface analysis of the nanofibers was studied by field emission scanning electron microscopy. The wetting and dissolution time of the scaffolds and drug release rate were studied as well. The drug-loaded PVP fibers showed better quality regarding size and homogeneity compared to drug-loaded PVA fibers. These fibers encapsulated approximately 2.5 mg/cm2 of the drug and achieved immediate controlled released rate, which is encouraging for further studies leading to an alternative treatment of PAH in children.
2020
Artículo
e-Polymers, 20(1), 746-758.
Inglés
Torres-Martínez, E. J., Vera-Graziano, R., Cervantes-Uc, J. M., Bogdanchikova, N., Olivas-Sarabia, A., Valdez-Castro, R., ... & Villarreal-Gómez, L. J. (2020). Preparation and characterization of electrospun fibrous scaffolds of either PVA or PVP for fast release of sildenafil citrate. e-Polymers, 20(1), 746-758.
PROPIEDADES DE LOS MATERIALES
Versión publicada
publishedVersion - Versión publicada
Appears in Collections:Artículos de Investigación Arbitrados

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