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http://cicy.repositorioinstitucional.mx/jspui/handle/1003/2062| Similar features, different behaviors: A comparative in vitro study of the adipogenic potential of stem cells from human follicle, dental pulp, and periodontal ligament | |
| Melissa D. Mercado Rubio Erick Pérez Argueta ALEJANDRO ZEPEDA PEDREGUERA Fernando Javier Aguilar-Ayala Ricardo Peñaloza_Cuevas ANGELA FRANCISCA KU GONZALEZ Rafael Antonio Rojas Herrera BEATRIZ ADRIANA RODAS JUNCO Geovanny I. Nic-Can | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.3390/jpm11080738 | |
| https://doi.org/10.3390/jpm11080738 | |
| ADIPOGENESIS CELLULAR DIFFERENTIATION DENTAL TISSUE-DERIVED MESENCHYMAL STEM CELLS DENTAL PULP CELLS DENTAL FOLLICLE CELLS PERIODONTAL LIGAMENT CELLS | |
| Dental tissue-derived mesenchymal stem cells (DT-MSCs) are a promising resource for tissue regeneration due to their multilineage potential. Despite accumulating data regarding the biology and differentiation potential of DT-MSCs, few studies have investigated their adipogenic capacity. In this study, we have investigated the mesenchymal features of dental pulp stem cells (DPSCs), as well as the in vitro effects of different adipogenic media on these cells, and compared them to those of periodontal ligament stem cells (PLSCs) and dental follicle stem cells (DFSCs). DFSC, PLSCs, and DPSCs exhibit similar morphology and proliferation capacity, but they differ in their self-renewal ability and expression of stemness markers (e.g OCT4 and c-MYC). Interestingly, DFSCs and PLSCs exhibited more lipid accumulation than DPSCs when induced to adipogenic differentiation. In addition, the mRNA levels of adipogenic markers (PPAR, LPL, and ADIPOQ) were significantly higher in DFSCs and PLSCs than in DPSCs, which could be related to the differences in the adipogenic commitment in those cells. These findings reveal that the adipogenic capacity differ among DT-MSCs, features that might be advantageous to increasing our understanding about the developmental origins and regulation of adipogenic commitment. | |
| 2021 | |
| Artículo | |
| Journal of personalized medicine, 11(8), 738, 2021. | |
| Español | |
| Mercado-Rubio, M. D., Pérez-Argueta, E., Zepeda-Pedreguera, A., Aguilar-Ayala, F. J., Peñaloza-Cuevas, R., Kú-González, A., ... & Nic-Can, G. I. (2021). Similar features, different behaviors: A comparative in vitro study of the adipogenic potential of stem cells from human follicle, dental pulp, and periodontal ligament. Journal of personalized medicine, 11(8), 738. | |
| BIOLOGÍA MOLECULAR DE PLANTAS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
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