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http://cicy.repositorioinstitucional.mx/jspui/handle/1003/2135| Comparative genomics of DNA-binding transcription factors in archaeal and bacterial organisms | |
| Luis Martinez Liu Rafael Hernandez Guerrero NANCY RIVERA GOMEZ Mario Alberto Martínez Núñez Pedro Javier Escobar Turriza Eveline Peeters Perez-Rueda Ernesto | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1371/journal.pone.0254025 | |
| ARCHAEA BACTERIA DNA, ARCHAEAL DNA, BACTERIAL GENOME SIZE GENOME, ARCHAEAL GENOME, BACTERIAL GENOMICS ISOELECTRIC POINT | |
| Archaea represent a diverse phylogenetic group that includes free-living, extremophile, mesophile, symbiont, and opportunistic organisms. These prokaryotic organisms share a high significant similarity with the basal transcriptional machinery of Eukarya, and they share regulatory mechanisms with Bacteria, such as operonic organization and DNA-binding transcription factors (TFs). In this work, we identified the repertoire of TFs in 415 archaeal genomes and compared them with their counterparts in bacterial genomes. The comparisons of TFs, at a global level and per family, allowed us to identify similarities and differences between the repertoires of regulatory proteins of bacteria and archaea. For example, 11 of 62 families are more highly abundant in archaea than bacteria, and 13 families are abundant in bacteria but not in archaea and 38 families have similar abundances in the two groups. In addition, we found that archaeal TFs have a lower isoelectric point than bacterial proteins, i.e., they contain more acidic amino acids, and are smaller than bacterial TFs. Our findings suggest a divergence occurred for the regulatory proteins, even though they are common to archaea and bacteria. We consider that this analysis contributes to the comprehension of the structure and functionality of regulatory protein of archaeal organisms. | |
| 2021 | |
| Artículo | |
| PLoS ONE 16(7): e0254025. https://doi.org/10.1371/journal.pone.0254025 | |
| Inglés | |
| Martinez-Liu L, Hernandez-Guerrero R, Rivera-Gomez N, Martinez-Nuñez MA, Escobar-Turriza P, Peeters E, et al. (2021) Comparative genomics of DNA-binding transcription factors in archaeal and bacterial organisms. PLoS ONE 16(7): e0254025. https://doi.org/10.1371/journal.pone.0254025 | |
| BIOLOGÍA MOLECULAR DE PLANTAS | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
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| 2021_Luis_Martinez_Liu.pdf | 1.14 MB | Adobe PDF | Visualizar/Abrir |