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http://cicy.repositorioinstitucional.mx/jspui/handle/1003/221| Metabolites from roots of Colubrina greggii var. yucatanensis and evaluation of their antiprotozoan, cytotoxic and antiproliferative activities | |
| LUIS MANUEL PEÑA RODRIGUEZ | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| http://dx.doi.org/10.1590/S0103-50532011000700013 | |
| http://dx.doi.org/10.1590/S0103-50532011000700013 | |
| http://dx.doi.org/10.1590/S0103-50532011000700013 | |
| Purification of the root extract of Colubrina greggii var. yucatanensis resulted in the isolation and identification of 3-O-acetyl ceanothic acid as a new natural ceanothane triterpene, together with the known metabolites ceanothic acid, cenothenic acid, betulinic acid, discarine B and chrysophanein. The natural products and the semisynthetic esters acetyl dimethyl ceanothate, dimethyl ceanothate and chrysophanein peracetate showed moderate to low leishmanicidal and trypanocidal activities. None of the metabolites showed cytotoxic or antiproliferative effects. The results also suggested that betulinic acid contributes to the antiplasmodial activity originally detected in the crude root extract of C. greggii var. yucatanensis. | |
| 11-03-2011 | |
| Artículo | |
| Inglés | |
| Bibliotecarios Estudiantes Investigadores Maestros | |
| OTRAS | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
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| 18140.pdf | Colubrina greggii var. yucatanensis; Rhamnaceae; antiprotozoan; cytotoxic ceanothane | 223.33 kB | Adobe PDF | Visualizar/Abrir |