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http://cicy.repositorioinstitucional.mx/jspui/handle/1003/2257| Apoptotic and cell cycle effects of triterpenes isolated from Phoradendron wattii on leukemia cell lines | |
| LIA SARAHI VALENCIA CHAN Dafné Linda Moreno Lorenzana JIMMY JOSUE CEBALLOS CRUZ SERGIO RUBEN PERAZA SANCHEZ ANTONIETA CHAVEZ-GONZALEZ ROSA MOO_PUC | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| DOI: 10.3390/molecules27175616 | |
| LEUKEMIA LUPANE-TYPE TRITERPENE APOPTOSIS CELL CYCLE MOLECULAR DOCKING | |
| Current antineoplastic agents present multiple disadvantages, driving an ongoing search for new and better compounds. Four lupane-type triterpenes, 3α,24-dihydroxylup-20(29)-en-28-oic acid (1), 3α,23-dihydroxy-30-oxo-lup-20(29)-en-28-oic acid (2), 3α,23-O-isopropylidenyl-3α,23-dihydroxylup-20(29)-en-28-oic acid (3), and 3α,23-dihydroxylup-20(29)-en-28-oic acid (4), previously isolated from Phoradendron wattii, were evaluated on two cell lines of chronic (K562) and acute (HL60) myeloid leukemia. Compounds 1, 2, and 4 decreased cell viability and inhibit proliferation, mainly in K562, and exhibited an apoptotic effect from 24 h of treatment. Of particular interest is compound 2, which caused arrest in active phases (G2/M) of the cell cycle, as shown by in silico study of the CDK1/Cyclin B/Csk2 complex by molecular docking. This compound [3α,23-dihydroxy-30-oxo-lup-20(29)-en-28-oic acid] s a promising candidate for incorporation into cancer treatments and deserves further study. © 2022 by the authors. | |
| 2022 | |
| Artículo | |
| Molecules, 27(17), 5616, 2022. | |
| Inglés | |
| Valencia-Chan, L.S.; Moreno-Lorenzana, D.; Ceballos-Cruz, J.J.; Peraza-Sánchez, S.R.; Chávez-González, A.; Moo-Puc, R.E. Apoptotic and Cell Cycle Effects of Triterpenes Isolated from Phoradendron wattii on Leukemia Cell Lines. Molecules 2022, 27, 5616. https://doi.org/10.3390/molecules27175616 | |
| BIOLOGÍA MOLECULAR | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
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