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http://cicy.repositorioinstitucional.mx/jspui/handle/1003/2674| Citroflavonoids as promising agents for drug discovery in diabetes and hypertension: A systematic review of experimental studies | |
| ROLFFY RUBEN ORTIZ ANDRADE JESUS ALFREDO ARAUJO LEON Juan Carlos Sanchez_Salgado AMANDA SANCHEZ_RECILLAS Priscila Vazquez-Garcia EMANUEL HERNANDEZ NUÑEZ | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.3390/molecules27227933 | |
| BIOCHEMICAL PARAMETERS BLOOD MARKERS GENE EXPRESSION HESPERIDIN NARINGENIN PROTEIN CONTENT | |
| Flavonoids are naturally occurring compounds widely distributed in the Citrus genus. These natural compounds have many health benefits, mainly for metabolic and cardiovascular diseases. In fact, some these compounds are components of drug products with approved indications for peripheral vascular insufficiency and hemorrhoids. However, information on pharmacological effects of these compounds remains disperse and there is scarce comprehensive analysis of whole data and evidence. These kinds of evidence analyses could be necessary in drug design and the development of novel and innovate drug products in diabetes and hypertension. We aimed to systematically search for evidence on the efficacy of citroflavonoids in diabetes and hypertension in in vivo models. We searched four literature databases based on a PICO strategy. After database curation, twenty-nine articles were retrieved to analyze experimental data. There was high heterogeneity in both outcomes and methodology. Naringenin and hesperetin derivates were the most studied citroflavonoids in both experimental models. More investigation is still needed to determine its potential for drug design and development. © 2022 by the authors. | |
| 2022 | |
| Artículo | |
| Molecules 2022, 27, 7933.https://doi.org/10.3390/molecules27227933 | |
| Inglés | |
| Ortiz-Andrade, R.; Araujo León, J.A.; Sánchez-Salgado, J.C.; Sánchez-Recillas, A.; Vazquez-Garcia, P.; Hernández-Núñez, E. Citroflavonoids as Promising Agents for Drug Discovery in Diabetes and Hypertension: A Systematic Review of Experimental Studies. Molecules 2022, 27, 7933.https://doi.org/10.3390/molecules27227933 | |
| BIOLOGÍA MOLECULAR | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
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