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http://cicy.repositorioinstitucional.mx/jspui/handle/1003/3126| Porous chitosan hydrogels produced by physical crosslinking: physicochemical, structural, and cytotoxic properties | |
| Ana Gabriela Fletes Vargas Hugo Espinosa-Andrews JOSE MANUEL CERVANTES UC Isaias Limón Rocha Gabriel Luna-Barcenas Milton Vazquez-Lepe Norma Morales Hernández Jorge Armando Jiménez Ávalos DANTE GUILLERMO MEJIA TORRES Paris Ramos-Martinez Rogelio Rodríguez Rodríguez | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.3390/polym15092203 | |
| CHITOSAN PHYSICAL CROSSLINKING HYDROGELS POROUS XPS ANALYSIS POROUS STRUCTURE CYTOTOXICITY | |
| Chitosan hydrogels are biomaterials with excellent potential for biomedical applications. In this study, chitosan hydrogels were prepared at different concentrations and molecular weights by freeze-drying. The chitosan sponges were physically crosslinked using sodium bicarbonate as a crosslinking agent. The X-ray spectroscopy (XPS and XRD diffraction), equilibrium water content, microstructural morphology (confocal microscopy), rheological properties (temperature sweep test), and cytotoxicity of the chitosan hydrogels (MTT assay) were investigated. XPS analysis confirmed that the chitosan hydrogels obtained were physically crosslinked using sodium bicarbonate. The chitosan samples displayed a semi-crystalline nature and a highly porous structure with mean pore size between 115.7 ± 20.5 and 156.3 ± 21.8 µm. In addition, the chitosan hydrogels exhibited high water absorption, showing equilibrium water content values from 23 to 30 times their mass in PBS buffer and high thermal stability from 5 to 60 °C. Also, chitosan hydrogels were non-cytotoxic, obtaining cell viability values ≥ 100% for the HT29 cells. Thus, physically crosslinked chitosan hydrogels can be great candidates as biomaterials for biomedical applications. | |
| 2023 | |
| Artículo | |
| Polymers. 15, 2203, 2023. | |
| Inglés | |
| Fletes-Vargas, G.; Espinosa-Andrews, H.; Cervantes-Uc, J.M.; Limón-Rocha, I.; Luna-Bárcenas, G.; Vázquez-Lepe, M.; Morales-Hernández, N.; Jiménez-Ávalos, J.A.; Mejía-Torres, D.G.; Ramos-Martínez, P.; et al. Porous Chitosan Hydrogels Produced by Physical Crosslinking: Physicochemical, Structural, and Cytotoxic Properties. Polymers 2023, 15, 2203. https://doi.org/10.3390/polym15092203 | |
| PROPIEDADES DE LOS MATERIALES | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
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| 2023_Gabriela_Fletes.pdf | 3.09 MB | Adobe PDF | Visualizar/Abrir |