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Quinones as promising compounds against respiratory viruses: a review
IVAN HUMBERTO CHAN ZAPATA
ROCIO DE LOURDES BORGES ARGAEZ
GUADALUPE AYORA TALAVERA
Acceso Abierto
Atribución-NoComercial-SinDerivadas
10.3390/molecules28041981
INFLUENZA
SARS-CoV-2
NAPHTHOQUINONE
ANTHRAQUINONE
BENZOQUINONE
ANTIVIRALS
NATURAL COMPOUNDS
SYNTHETIC QUINONES
Respiratory viruses represent a world public health problem, giving rise to annual seasonal epidemics and several pandemics caused by some of these viruses, including the COVID-19 pandemic caused by the novel SARS-CoV-2, which continues to date. Some antiviral drugs have been licensed for the treatment of influenza, but they cause side effects and lead to resistant viral strains. Likewise, aerosolized ribavirin is the only drug approved for the therapy of infections by the respiratory syncytial virus, but it possesses various limitations. On the other hand, no specific drugs are licensed to treat other viral respiratory diseases. In this sense, natural products and their derivatives have appeared as promising alternatives in searching for new compounds with antiviral activity. Besides their chemical properties, quinones have demonstrated interesting biological activities, including activity against respiratory viruses. This review summarizes the activity against respiratory viruses and their molecular targets by the different types of quinones (both natural and synthetic). Thus, the present work offers a general overview of the importance of quinones as an option for the future pharmacological treatment of viral respiratory infections, subject to additional studies that support their effectiveness and safety.
2023
Artículo
Molecules 2023, 28, 1981. https://doi.org/10.3390/ molecules28041981
Inglés
Chan-Zapata, I.; Borges-Argáez, R.; Ayora-Talavera, G. Quinones as Promising Compounds against Respiratory Viruses: A Review. Molecules 2023, 28, 1981. https://doi.org/10.3390/ molecules28041981
FARMACOLOGÍA MOLECULAR
Versión publicada
publishedVersion - Versión publicada
Aparece en las colecciones: Artículos de Investigación Arbitrados

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