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http://cicy.repositorioinstitucional.mx/jspui/handle/1003/501| Antiproliferative and antiestrogenic activities of bonediol an alkyl catechol from bonellia macrocarpa | |
| ROSA ESTHER MOO PUC | |
| EDGAR EMMANUEL CAAMAL FUENTES SERGIO RUBEN PERAZA SANCHEZ | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| DOI: 10.1155/2015/847457 | |
| ANTIESTROGEN ANTINEOPLASTIC AGENT BONEDIOL CATECHOL CYCLOPAMINE | |
| The purpose of this study was to investigate antiproliferative activity of bonediol, an alkyl catechol isolated from the Mayan medicinal plant Bonellia macrocarpa. Bonediol was assessed for growth inhibition of androgen-sensitive (LNCaP), androgen-insensitive (PC-3), and metastatic androgen-insensitive (PC-3M) human prostate tumor cells; toxicity on normal cell line (HEK 293) was also evaluated. Hedgehog pathway was evaluated and competitive 3H-estradiol ligand binding assay was performed. Additionally, antioxidant activity on Nrf2-ARE pathway was evaluated. Bonediol induced a growth inhibition on prostate cancer cell lines (IC50 from 8.5 to 20.6 μM). Interestingly, bonediol binds to both estrogen receptors (ERα (2.5 μM) and ERβ (2.1 μM)) and displaces the native ligand E2 (17β-estradiol). No significant activity was found in the Hedgehog pathway. Additionally, activity of bonediol on Nrf2-ARE pathway suggested that bonediol could induce oxidative stress and activation of detoxification enzymes at 1 μM (3.8-fold). We propose that the compound bonediol may serve as a potential chemopreventive treatment with therapeutic potential against prostate cancer. | |
| 2015 | |
| Artículo | |
| BioMed Research International. Article ID 847457, (1-6), 2015 | |
| Inglés | |
| Moo-Puc, R., Caamal-Fuentes, E., Peraza-Sánchez, S. R., Slusarz, A., Jackson, G., Drenkhahn, S. K., & Lubahn, D. B. (2015). Antiproliferative and antiestrogenic activities of bonediol an alkyl catechol from bonellia macrocarpa. BioMed Research International, 2015 doi:10.1155/2015/847457 | |
| BIOLOGÍA Y QUÍMICA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos de Investigación Arbitrados |
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| 2015_AI_id37798_Sergio_Peraza.pdf | 1.32 MB | Adobe PDF | Visualizar/Abrir |