Please use this identifier to cite or link to this item: http://cicy.repositorioinstitucional.mx/jspui/handle/1003/516
Isolation and identification of cytotoxic compounds from Aeschynomene fascicularis, a Mayan medicinal plant
ROSA ESTHER MOO PUC
EDGAR EMMANUEL CAAMAL FUENTES
SERGIO RUBEN PERAZA SANCHEZ
LUIS WILIUNFO TORRES TAPIA
Acceso Abierto
Atribución-NoComercial-SinDerivadas
DOI: 10.3390/molecules200813563
FABACEAE
FLAVONOIDS
MAYAN MEDICINAL PLANT
ANTIPROLIFERATIVE ACTIVITY
CYTOTOXIC ACTIVITY
The plant Aeschynomene fascicularis (Fabaceae) has been used in Mayan traditional medicine in the Yucatan peninsula. However, the compounds present in the plant responsible for its curative properties have not yet been investigated. Aeschynomene fascicularis root bark was extracted with 100% methanol to obtain a crude extract. The methanol extract was partitioned successively with solvents with increasing polarity to obtain the corresponding hexane (Hx), dichloromethane (DCM) and ethyl acetate fractions (EtOAc), as well as a residual water-alcoholic fraction. These fractions were tested for their cytotoxic activities using an MTT assay against Hep-2 cancer cell lines. The Hx fraction led to the isolation of spinochalcone C (1), spinochalcone A (2), isocordoin (3) and secundiflorol G (4). Their structures were identified based on spectroscopic evidence and chemical properties. All compounds were subjected to cytotoxicity and antiproliferative assays against a panel of seven cell lines, including one normal-type cell line. Spinochalcone A (2) exhibited cytotoxic activity against DU-145 cell line and antiproliferative activity against the KB cell line. Secundiflorol G (4) showed strong cytotoxic activity towards KB and Hep-2 cell lines. In addition, isocordoin (3) showed moderate activity on KB, Hep-2 and DU-145 cell lines. The active Compounds 2, 3 and 4 are potential therapeutic entities against cancer.
01-08-2015
Artículo
Molecules. 20(8), 13563-13574, 2015
Inglés
Caamal-Fuentes, E. E., Peraza-Sánchez, S. R., Torres-Tapia, L. W., & Moo-Puc, R. E. (2015). Isolation and identification of cytotoxic compounds from Aeschynomene fascicularis, a Mayan medicinal plant. Molecules, 20(8), 13563-13574.
BIOLOGÍA Y QUÍMICA
Versión publicada
publishedVersion - Versión publicada
Appears in Collections:Artículos de Investigación Arbitrados

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