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Antibacterial behavior of chitosan-sodium hyaluronate-PEGDE crosslinked films
Martha Gabriela Chuc-Gamboa
Carolina María Cámara Perera
Fernando Javier Aguilar-Ayala
ROSSANA FARIDE VARGAS CORONADO
JUAN VALERIO CAUICH RODRIGUEZ
DIANA MARIA ESCOBAR GARCIA
Luis Octavio Sanchez Vargas
Neith Pacheco López
Julio San Roman Del Barrio
Acceso Abierto
Atribución-NoComercial-SinDerivadas
https://doi.org/10.3390/app11031267
CHITOSAN
SODIUM HYALURONATE
PEGDE
ANTIBACTERIAL
ESCHERICHIA COLI
ENTEROCOCCUS FAECALIS
STAPHYLOCOCCUS AUREUS
SALMONELLA TYPHIMURION
Chitosan is a natural polymer that can sustain not only osteoblast adhesion and proliferation for bone regeneration purposes, but it is also claimed to exhibit antibacterial properties towards several Gram-positive and Gram-negative bacteria. In this study, chitosan was modified with sodium hyaluronate, crosslinked with polyethylene glycol diglycidyl ether (PEGDE) and both osteoblast cytotoxicity and antibacterial behavior studied. The presence of sodium hyaluronate and PEGDE on chitosan was detected by FTIR, XRD, and XPS. Chitosan (CHT) films with sodium hyaluronate crosslinked with PEGDE showed a better thermal stability than pristine hyaluronate. In addition, osteoblast cytocompatibility improved in films containing sodium hyaluronate. However, none of the films exhibit antimicrobial activity against Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus while exhibiting low to mild activity against Salmonella typhimurion.
2021
Artículo
Applied Sciences, 11(3), 1267, 2021.
Inglés
Chuc-Gamboa, M.G.; Cámara Perera, C.M.; Aguilar Ayala, F.J.; Vargas-Coronado, R.F.; Cauich-Rodríguez, J.V.; Escobar-García, D.M.; Sánchez-Vargas, L.O.; Pacheco, N.; San Román del Barrio, J. Antibacterial Behavior of Chitosan-Sodium Hyaluronate-PEGDE Crosslinked Films. Appl. Sci. 2021, 11, 1267. https://doi.org/10.3390/app1103 1267
PROPIEDADES DE LOS MATERIALES
Versión publicada
publishedVersion - Versión publicada
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